Frank De Los Santos was a member of the starting rotation for the Stone Crabs during the 2010 season and then moved to the bullpen to start the 2011 season before being promoted to Montgomery two weeks into the 2011 season. He was a combined 10-10 with a 5.08 ERA and 113 strikeouts in 28 games with the Stone Crabs.
De Los Santos was signed as an international free agent in 2006. He began his career in the states in 2007 with the Princeton Devil Rays. He spent 2008 with the Hudson Valley Renegades, 2009 with the Bowling Green Hot Rods and 2010 with the Stone Crabs.